A groundbreaking study has examined the potential of a hemp-derived, broad-spectrum, high-CBD vaginal suppository (100 mg) in alleviating menstrual-related pain and discomfort. The research, published in npj Women’s Health in August 2024, was funded by Foria/Praxis Ventures, the brand behind the suppository used in the study.
First-of-Its-Kind Research on CBD Suppositories for Menstrual Symptoms
This study marks the first investigation into a commercially available high-CBD suppository for menstrual-related symptoms. Researchers conducted a survey-based, quasi-experimental study involving 307 participants. Among them, 33 individuals used CBD suppositories to manage menstrual symptoms, while 230 participants followed their usual treatment methods (TAU group) and did not use the suppository.
Participants completed online questionnaires at baseline and during two monthly follow-ups to assess the suppository’s effectiveness.
CBD Suppositories Show Promising Results for Menstrual Pain
Building on prior research into medical cannabis for menstrual relief, the study hypothesized that CBD users would experience significant improvements in symptoms, daily functioning, and reduced reliance on painkillers compared to the TAU group.
Key findings from the study include:
- Participants using high-CBD suppositories reported greater symptom improvement over two months compared to the TAU group.
- CBD suppositories appeared to be more effective for congestive pain (dull, aching discomfort with mood and energy-related symptoms) rather than spasmodic pain (sharp, cramping pains).
- The CBD group experienced improvements in daily life impact, such as reduced avoidance of activities due to menstrual symptoms.
- Participants using suppositories decreased their reliance on analgesics (pain relievers).
- Data suggested a potential dose-dependent response, meaning higher use of CBD suppositories may lead to greater symptom relief.
Study Limitations and Future Research Directions
Despite its promising findings, the study faced limitations. Since the CBD suppository is commercially available, it was ineligible for clinical trials, preventing researchers from direct clinical interactions with participants. As a result, adverse effects could not be formally recorded.
To address these gaps, researchers recommend that future studies conduct clinical trials to explore:
- Potential side effects of CBD suppositories.
- Pharmacokinetics and pharmacodynamics (how the body absorbs and processes CBD).
- Broader applications for gynecological conditions beyond menstrual pain.
As interest in natural alternatives for menstrual pain relief continues to grow, this study provides valuable insights into the potential role of CBD-based treatments. Further research could pave the way for more regulated and clinically approved cannabinoid therapies for women’s health.
Reference :
- Dahlgren, M.K., Smith, TR., Kosereisoglu, D., Sagar, KA., Lambros, AM., El-Abboud, C., and Gruber, SA. A survey-based, quasi-experimental study assessing a high-cannabidiol suppository for menstrual-related pain and discomfort. npj Women’s Health. 2024. DOI: 10.1038/s44294-024-00032-0
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